Pressing pain behind the ear can be seen in skin infection behind the ear, lymphadenitis behind the ear, mastoiditis of the middle ear and other diseases, which can be relieved by topical ointment, oral medication and antibiotic ear drops. 1. Skin infection behind the ear: if the infection behind the ear forms boils, there will be redness, swelling, heat and pain of the skin, which can be treated with anti-inflammatory ointment such as erythromycin ointment, mupirocin ointment, etc. If necessary, systemic application of broad-spectrum antibiotics, such as amoxicillin-clavulanic acid potassium, cefuroxime, roxithromycin and so on. 2. Post-auricular lymphadenitis: there will be localized bulging and pain behind the ear, oral antibiotics such as amoxicillin and other penicillin drugs, if allergic to penicillin, then cephalosporins such as cefuroxime can be used. 3. Middle ear mastoiditis: otitis media should be treated promptly with the above antibiotic systemic treatment as well as local antibiotic ear drops such as ofloxacin ear drops. Pressure pain behind the ear, should be timely consultation, clear diagnosis and follow the doctor’s instructions for treatment.