The effect time of taking tranexamic acid to remove melasma varies from person to person, and the effect can be seen within 6-15 months after using the medicine. Melasma, commonly known as liver spot and butterfly spot, is a yellowish-brown pigmentation on the face, symmetrically distributed on the cheek in the shape of a butterfly. It is mostly seen in women, and its onset is related to pregnancy, long-term oral contraceptive use, menstrual disorders, etc. Tranexamic acid can inhibit the stimulation of melanocytes by various cytokines, which can reduce the synthesis of melanin. At the same time, tranexamic acid is very similar to the structure of the rate-limiting enzyme called tyrosinase in the process of melanin synthesis in chemical structure, so tranexamic acid has certain efficacy on melasma. However, the treatment period is relatively long, and it is easy to recur. Oral tranexamic acid can gradually eliminate the pigmentation, and it is recommended to take low dose for a long time, which usually takes 6-15 months of treatment cycle. Therefore, the effect time is relatively late, and it is necessary to insist on the medication. It is necessary to abstain from alcohol, avoid spicy and stimulating food, and ensure sufficient sleep time during the medication period, which will be helpful to the treatment.