Skin peeling after treatment of pubic lice may be caused with drug irritation, skin damage caused by pubic lice disease, or skin peeling manifestation caused by fungal infection, vulvar leukoplakia, pubic eczema and other conditions, which are dealt with by means of life conditioning and drug treatment. 1. Drug stimulation: As pubic lice need to be treated by applying medication such as sulfur ointment, the medication may cause skin irritation, leading to skin peeling after treatment. Avoid bathing with hot water at too high a temperature while paying attention to moisturizing, which can usually be relieved on its own. 2. Damaged skin of pubic lice disease: due to the bite of pubic lice bugs, it will lead to the injury of the skin in the area, and after recovery, there may be slight peeling phenomenon. It can usually be relieved by itself and does not need special treatment. 3. Fungal infection: If the area is infected by fungus after recovery, it will cause local itching and white flakes. You need to apply clotrimazole cream, miconazole cream and other treatments. 4. Vulvar leukoplakia: Vulvar leukoplakia will lead to symptoms such as loss of pubic pigment, peeling, flaking and itching. It can be controlled by topical medication such as progesterone cream and tacrolimus cream. 5. Pubic eczema: If the patient has eczema in the pubic area, it will cause local itching, flaking and rash, etc. It can be relieved by applying glycerite lotion and treated with oral loratadine and cetirizine hydrochloride. Due to the complexity of the etiology, it is recommended that patients seek timely medical attention, after a clear diagnosis, strictly comply with the doctor’s instructions for treatment.