The cause of fever, chills and shivering should be identified and treated. It may be caused by common cold, hypothyroidism, acute pyelonephritis, etc. and can be treated with medication. 1. Common cold: It may be caused by bacterial or viral infections, and may be triggered by cold and rain, with fever and chills. Antipyretic and analgesic drugs such as acetaminophen and aspirin can be used to relieve fever, pain and muscle aches. 2. Hypothyroidism: It is mainly caused by insufficient secretion of thyroid hormone, and may have symptoms such as chills and fatigue. Levothyroxine can be taken under the guidance of a doctor, and iodine supplementation is also needed in case of iodine deficiency. 3. Acute pyelonephritis: It is mainly caused by infection, and may also be caused by urinary tract obstruction and reflux, cold and other factors, mainly manifested as lumbar pain, urinary tract irritation, but also high fever, chills and other uncomfortable symptoms. Quinolone antibacterial drugs, such as ciprofloxacin and other antibacterial treatment can be used, but also oral compound sulfamethoxazole tablets. Fever chills and shivering is recommended to go to the hospital in time, by the doctor to identify the cause of the disease to take symptomatic treatment, to avoid delaying the condition.