Can hyperuricemia cause uremia? What you don’t know about the dangers of hyperuric acid. Hyperuricemia is a disease caused by long-term purine metabolism disorder, very common in obese people, about 85% of patients start to find kidney lesions after 30 years old, and the disease progresses slowly, reaching chronic renal failure and life-threatening after 10-20 years. The deposition of uric acid in the kidney causes inflammation and damage to the kidney tissue called gouty nephropathy. Uric acid is mainly deposited in the renal interstitium and tubules, and the tubular epithelium atrophies and degenerates, and impairs tubular function. The interstitial kidney may develop edema and inflammatory reaction, and even fibrosis, which is clinically called interstitial nephritis. A small amount of proteinuria, microscopic or meatus hematuria, swelling, and moderate hypertension may occur clinically. About 20% of gout patients develop kidney stones. The higher the concentration of uric acid in the blood, the greater the likelihood of urinary stones. Stones obstructing the ureter can cause severe back pain and hematuria. Stones are often not detected by abdominal X-rays and can be confirmed by intravenous pyelogram. The kidney does not beat like the heart, nor does it feel bloated and painful like the stomach due to overeating; it plays the role of a “scavenger” in the body, filtering and removing metabolic products. Because of this, the damage it suffers is silent; by the time symptoms appear, the kidney may have lost most of its function, affecting not only the urinary system, but also the circulatory system, which is very harmful to health. How many times, when people come to our doctors with symptoms, the examination is “advanced kidney disease”, and they miss the best treatment time and regret for their life. Why is this? Because the clinical manifestations of kidney disease are diverse and not very specific. At the beginning of the disease, patients can not have any discomfort, even if some discomfort, it is not easy to attract attention. Many patients often take medication on their own; some patients do not think they have the disease and have never seen a doctor, and the first time they know they have kidney disease, they have already reached the stage of renal failure – uremia. More than one million people around the world are now surviving on dialysis and are growing at an average rate of 8% per year. Clinical evidence shows that the onset of chronic kidney disease is also showing a trend of rejuvenation, many uremic patients are only 20 to 30 years old, the youngest is only a few years old. The author has treated patients with uremia who started dialysis at the age of 8 and are now 23 years old, and these patients often spend a lot of financial and material resources, and some eventually have to give up treatment.