A high level of this indicator in urine suggests possible nephritis, glomerulonephritis, nephrotic syndrome, diabetic nephropathy and hepatitis B-associated nephropathy are all possible conditions. When the kidney function is impaired, the filtration function of glomerulus and renal tubules decreases, so these small molecules of immunoglobulin can be excreted through urine, which is a manifestation of kidney damage. Clinical symptoms may also include facial swelling, sudden decrease in urine volume, hypertension, hyperlipidemia, and hypoproteinemia. It is recommended that 24-hour urine protein quantification, 24-hour urine biochemistry, kidney function, renal ultrasound, kidney CT, kidney puncture and other tests can be done at the hospital to help clarify the cause of the disease and determine the diagnosis before further treatment under the guidance of the doctor.