The painful ejaculation is usually due to prostatitis, vesiculitis, etc. It is recommended to go to the urology department of a tertiary hospital to do routine urine, prostate fluid routine examination and semen routine examination to make a clear diagnosis. If the diagnosis of prostatitis is confirmed, it is recommended to take broad-spectrum anti-inflammatory drugs and Chinese anti-inflammatory drugs for treatment: 1. Broad-spectrum anti-inflammatory drugs include tetracycline anti-inflammatory drugs or quinolone anti-inflammatory drugs, such as methomycin, levofloxacin, moxifloxacin, etc.; 2. Chinese anti-inflammatory drugs include Zegui retention of urine, retention of urine Shu. If it is diagnosed to be caused by seminal vesiculitis, it is recommended to take cephalosporin anti-inflammatory drugs or quinolone anti-inflammatory drugs for treatment, such as levofloxacin, moxifloxacin, cefdinir, cefixime and so on. During the treatment period, it is recommended not to drink alcohol and not to have frequent sexual intercourse, which also helps to improve the clinical symptoms of painful ejaculation. Also pay attention to a light diet, do not overexert yourself and do not stay up late.