Pentavalent is known as Pentavalent Vaccine, which is a combination of five vaccines, including pertussis, diphtheria, tetanus, polio, and Haemophilus influenzae type B. Pentavalent Rotavirus is known as Pentavalent Rotavirus Vaccine, and it is not recommended that Pentavalent and Pentavalent Rotavirus Vaccine be given together. Pentavalent rotavirus vaccine may also interact with the pentavalent vaccine and exacerbate adverse reactions after vaccination. Pentavalent vaccine may cause adverse reactions such as fever, diarrhea, vomiting, and loss of appetite after injection, while pentavalent rotavirus vaccine may cause mild adverse reactions such as fever, drowsiness, rash, tenderness, erythema, and hardness, etc., and administering the two vaccines together may cause aggravation of the adverse reactions. At the same time, if Pentavalent and Pentavalent Rotavirus vaccines are administered together, it is not possible to determine which vaccine caused the allergic reaction, which is not conducive to follow-up treatment. It is recommended to follow the doctor’s instructions when administering the vaccines.