1.Serologic tests should be performed immediately for HBV DNA, HBsAg, anti-HBs, HBeAg, anti-HBc, ALT and AST, and should be repeated within 3 and 6 months. 2.Active and passive immunization may not be specially treated if they have been vaccinated against hepatitis B and anti-HBs ≥10 mIU/mL is known. If the patient has not received hepatitis B vaccine, or has received hepatitis B vaccine but the anti-HBs <10 mIU/mL or the anti-HBs level is not known, the patient should be injected with HBIG 200~400 IU immediately, and at the same time, the patient should receive one injection of hepatitis B vaccine 20mg in different parts of the body, and then the patient should receive the second and third injections of hepatitis B vaccine 20mg in 1 and 6 months, respectively.