Uremia is caused by hypothalamic neuropituitary pathology, resulting in varying degrees of deficiency of antidiuretic hormone, which leads to dysfunction of water reabsorption in the renal tubules, resulting in increased urine output. It is clinically characterized by polyuria, irritable thirst, and hypospecific or hypotonic urine. Uremia is common in young adults, with a male-to-female ratio of 2:1.The majority of cases are due to central urolithiasis, which is categorized as primary, secondary, or hereditary. The cause of primary is unknown. Secondary is seen in cranial trauma, surgery of the hypothalamic pituitary gland, tumors, infectious diseases, vascular lesions, and autoimmune diseases. Renal factors are due to the lack of or decreased renal response to arginine pressin.