H. pylori positive 500 dpm/mmol is more serious, should be actively given anti-H. pylori treatment under the guidance of physicians. 1. There are more methods to detect H. pylori in the clinic, the normal range of carbon 14 breath test should be 0~100 dpm/mmol, and the normal range of carbon 13 breath test should be 0~4 dpm/mmol. No matter which kind of breath test, H. pylori positive 500 dpm/mmol suggests that there is H. pylori infection in the patient’s body, and the common diseases are chronic gastritis, gastric ulcer, duodenal ulcer, gastric cancer and so on. 2. H. pylori is contagious, and the main way of transmission is oral-oral or fecal-oral. H. pylori positive people need to cooperate with the doctor to take quadruple therapy, follow the doctor’s advice to give amoxicillin, clarithromycin and other antibiotics, combined with omeprazole, lansoprazole and other proton pump inhibitors, and bismuth such as bismuth potassium citrate, colloidal bismuth pectin. Helicobacter pylori positive 500dpm/mmol patients need to follow the doctor’s instructions to improve further examination, to clarify the specific causes of the disease, for the primary disease to take targeted treatment.