H. pylori is a major causative agent of chronic active gastritis and an important cause of peptic ulcer development, which is transmitted mainly by oral-oral and fecal-oral routes. In recent years, the prevalence of H. pylori in children has increased, and chewing food before feeding children or sharing a bowl during meals may be the main modes of transmission of H. pylori infection. The common H. pylori-associated diseases in children are mainly chronic active gastritis, gastric ulcers and duodenal ulcers and, less commonly, gastric MALT lymphoma and, rarely, gastric adenocarcinoma. Therefore, the clinical manifestations of H. pylori infection are also the symptoms of these diseases, such as epigastric pain, fullness, early satiety, anorexia or upper gastrointestinal bleeding, etc. 1, children with chronic gastritis: there are different degrees of indigestion symptoms clinical manifestations of varying severity, and the course of the disease is prolonged. The main manifestation is recurrent, irregular abdominal pain, usually during or after meals, mostly located in the upper abdomen, around the umbilicus, some children with irregular sites, intermittent vague or dull pain in mild cases, severe colic in severe cases. It is often accompanied by loss of appetite, nausea, vomiting and abdominal distension, which then affects the nutritional status and growth and development. In cases of gastric mucosal erosion and bleeding, there is vomiting of blood and black stool. The clinical symptoms and signs are different due to the different sites, types and evolution of ulcers in each age group, and the younger the age, the less typical the symptoms are, and the clinical manifestations of patients at different ages have their own characteristics. Primary ulcers are common with gastric ulcers, manifesting as poor appetite, vomiting, crying after eating, abdominal distension, growth retardation, and also vomiting blood and black stools. These are the clinical symptoms of Helicobacter pylori infection in 1-year-old babies, parents should observe carefully to detect and treat the disease in time to avoid the prolongation of the disease affecting the baby’s development. However, the detection rate of H. pylori in 1-year-old babies is not very high, and it is not recommended to use random quadruple medication, but must be treated under the guidance of regular gastroenterology.