The effect of stomach cancer gene test targeted drug therapy is mainly related to the severity of the disease and the individual’s situation. Targeted drugs can directly destroy tumor cells and kill cancer cells, which can avoid the damage of other organs, and often replace immunotherapy to achieve the role of shrinking tumors, and the effect is more obvious under certain circumstances. Clinically, targeted drugs for gastric cancer mainly include trastuzumab, bevacizumab and cetuximab, which can control the disease to achieve the therapeutic effect under certain circumstances, but it cannot be generalized, as some patients do not have good effect and the cost is high, therefore, surgical treatment is the first choice of treatment plan.