ESBL is an acronym for ultra broad-spectrum beta-lactamase. ESBL is produced by bacteria that infect the human body and can break down antibiotics such as penicillins, cephalosporins and aminotransim, making these antibiotics ineffective against the bacteria or the bacteria resistant to these drugs. E. coli, Klebsiella pneumoniae, and Acinetobacter baumannii are most likely to produce this enzyme. If once diagnosed as ESBL positive strains, it is necessary to choose sensitive antibiotics, clinically mainly available carbapenems such as imipenem, meropenem; cephalosporins such as cefoxitin, cefmetazole; also can choose to add the enzyme inhibitors of penicillin or cephalosporins, such as piperacillin tazobactam, cefoperazone sulbactam.