Peeling of hands and feet may be caused by contact with irritating substances, eczema and tinea versicolor, etc. Patients can choose general treatment and medication to solve the problem according to different reasons. 1. Contact with irritating substances: long-term contact with disinfectant, soap and other chemical irritants will stimulate the local skin, resulting in peeling. Patients can choose to avoid contact with irritating substances to improve. 2. Eczema: hand and foot eczema can be manifested as erythema, papules, flaking with itching, can be treated with topical glucocorticoids such as mometasone furoate and other drugs. 3. Tinea pedis: when there is fungal infection in the hands and feet, it will also lead to the symptoms of peeling of the patient’s hands and feet. Patients can choose antibacterial drugs under the guidance of the doctor for treatment, such as terbinafine cream. When patients have symptoms of peeling skin on hands and feet, it is recommended to go to the hospital in time for examination and diagnosis, and under the guidance of the doctor for treatment.