The immune system of children is low and the body’s ability to resist germs is poor, so they are easily infected with mycoplasma, which causes mycoplasma pneumonia. The treatment of mycoplasma pneumonia needs to be timely. At this stage, the treatment of mycoplasma pneumonia in children is mainly based on medication, and respiratory isolation and care should be done. The treatment of pediatric mycoplasma pneumonia is based on the use of antibiotics that inhibit protein synthesis, including macrolides, chloramphenicol and tetracyclines. The specific method of use should be arranged by the clinician and strictly follow medical advice. Because mycoplasma infection is contagious, children with a history of close contact should be isolated from the respiratory tract as much as possible to prevent cross-infection. Children with severe hypoxia or airway obstruction should be treated with oxygen to prevent hypoxia. We also need to pay attention to care and diet, ensure that the child gets enough sleep, and keep the room air fresh. Children with severe mycoplasma pneumonia sometimes require aspiration and bronchial lavage. Treatment of pediatric mycoplasma pneumonia takes longer than treatment of common pneumonia, so parents need to be patient and give their children easily digestible, nutrient-rich foods and ensure adequate fluid intake.