Liver abscess eight centimeters can be treated by medication, percutaneous puncture drainage and surgical resection. 1. Drug treatment: (1) Liver abscess caused by bacterial infection needs timely application of antibiotic anti-infection treatment. The current liver abscess of eight centimeters requires the use of high-dose antibiotics such as cephalosporin antibiotics (cefoperazone, etc.), penicillin (amoxicillin, etc.), etc., to control inflammation and promote the absorption of inflammation. (2) Liver abscesses caused by fungi or amoebas require the application of antifungal drugs such as fluconazole and clarithromycin, and anti-amoebic drugs such as chloroquine and emetine. 2. Percutaneous puncture drainage: liver abscess eight centimeters in the application of antibiotic drug treatment at the same time can be ultrasound-guided puncture drainage, injection of antibiotics in the pus cavity, can promote the absorption of the abscess. 3. Surgical resection: If the conservative treatment has no effect, or affects the normal liver lobe, it is recommended to carry out timely surgical resection, and in serious cases, part of the liver lobe can be removed. Liver abscess eight centimeters need to be timely to the hospital for examination and treatment, so as not to delay the condition.