Persistent positive HPV type 16 requires cervical tissue biopsy, medication, and regular checkups. HPV is human papillomavirus, there are high-risk and low-risk types of infection. HPV high-risk infection has a certain relationship with the development of cervical cancer, most of the HPV is a transient infection, and it will be converted to negative by its own resistance. if HPV16 is persistently positive, it needs to be treated by the following methods. 1. Cervical biopsy: HPV16 persistent positivity requires colposcopy and cervical tissue biopsy to further exclude cervical lesions. 2. Medication: For HPV 16 persistent positive infection, localized vaginal treatment with antiviral drugs, such as interferon gel and povidone suppositories, should be used, and follow-up examination should be conducted after stopping the medication. 3. Regular checkups: HPV16 positive persistent infection needs regular cervical cancer screening. If you find that HPV16 is persistently positive, you need to choose reasonable examination and standardized treatment under the guidance of professional doctors to avoid delaying the condition.