With the gradual improvement in the understanding of the causes and treatments of lupus erythematosus, the prognosis of the disease has been significantly improved through early diagnosis and rational treatment, and the quality of life of patients is also being significantly improved, with the 10-year survival rate of patients with systemic lupus erythematosus exceeding 90%. The cause of death in lupus erythematosus is firstly progressive renal failure, followed by coma, psychosis and paralysis produced by vasculitis of the central nervous system, and the others are cardiopulmonary failure, infections, and adverse reactions to glucocorticoids. Early diagnosis and early treatment is the key to preventing complications. Once lupus nephritis, hematologic involvement and psychiatric symptoms have appeared, glucocorticoid shock therapy should be used in large doses at an early stage, or immunosuppressive drugs should be used in combination. In the course of hormone therapy, the adverse effects of hormones need to be prevented and dealt with in a timely manner.