A headache at night, mainly consider the following aspects of the cause: first, if it is hypertensive patients headache at night, to continuously monitor the blood pressure situation. There are some patients with unstable blood pressure control, if there is a rise in blood pressure, there will be a headache, at this time need to give antihypertensive drugs orally, after the blood pressure is normal, the patient’s headache can be relieved. Second, a headache at night, to ask the patient whether there is a history of migraine, some migraine in the acute attack, prone to fixed time or fixed parts of the headache. Third, headache at night, we should ask the patient whether there is fever, whether accompanied by nausea, vomiting, but also to go to the electroencephalogram examination, there are some atypical epilepsy can also be manifested as fixed-time headache.