Sprain of 90 degree inversion or eversion of ankle can easily lead to ligament strain of ankle joint or even avulsion fracture. Firstly, complete the examination to clarify the condition, and then give relative treatment measures, such as general treatment, physical therapy, medication and surgical treatment. 1. General treatment: after the sprain, firstly, it is recommended to reduce the activity of ankle joint, if necessary, brake and fixation, elevate the affected limb to promote the blood return, in order to alleviate the swelling and pain of the ankle joint. 2. Physiotherapy: In the acute stage of ankle sprain, local cold compresses can be applied to relieve pain and swelling. In the relief period, local hot compresses can be applied to promote local blood circulation, which can help reduce swelling and relieve pain. 3. Medication: When the pain is severe, ibuprofen and other painkillers can be given to treat the pain, and when the edema is obvious, mannitol and other dehydrating agents can be given to reduce the swelling of the ankle joint. 4. Surgery: If the sprain leads to ankle ligament rupture or serious fracture, surgical treatment is needed, such as ligament repair, fracture incision and internal fixation. After the sprain, it is recommended to go to the hospital in time to improve the auxiliary examination, in order to clarify the condition and take appropriate treatment measures. Because the drug has related side effects and contraindications, so need to be used under the guidance of a professional physician.