Gallbladder cancer is a highly malignant disease with rapid development and poor prognosis, and late-stage patients often combine with pain. For pain treatment, it is mainly dealt with in the following aspects: 1. For the cause of pain: bone pain caused by bone metastasis of gallbladder cancer can be alleviated by radiotherapy; 2. For the pain treatment of the tumor itself: now the international recommendation of three-step analgesic therapy for cancer pain is that according to the degree of pain of the patients, the patients can be analgesic by using non-opioid painkillers, or weak opioid or strong opioid painkillers. Generally speaking, through analgesic therapy, the pain of the vast majority of patients can be well controlled.