Feeling uncomfortable and painless in the scrotum may be caused by prostatitis, varicocele, orchitis and other diseases. 1. Prostatitis: Inflammation of the prostate gland caused by pathogenic bacterial infections or certain non-infectious factors, patients may experience discomfort in the pelvic region, abnormal urination, sexual dysfunction and other clinical manifestations. 2. Varicose veins of the spermatic cord: it refers to the blood stagnation of the spermatic cord’s trailing vascular plexus due to various reasons, resulting in localized venous dilatation and tortuosity, and in severe cases, the affected side of the scrotum may be enlarged, accompanied by a feeling of swelling and hidden pain. 3. Testiculitis: refers to the testicular inflammatory disease caused by bacterial or viral infection, the main manifestation of the affected side of the scrotum is red and swollen, there will be uncomfortable feeling, usually no obvious pain in the early stage. Feeling uncomfortable and pain in the scrotum may also be seen in acute testicular torsion, epididymal orchitis and other diseases, if the symptoms of feeling uncomfortable and pain in the scrotum, persistent and unrelieved, you need to consult a doctor for treatment.