Cefixime and amoxicillin are not recommended to be taken together. Amoxicillin belongs to the penicillin antibiotics, and cefixime is a cephalosporin class of drugs, the two drugs are the same target, if used at the same time, may lead to the drugs compete with each other’s role in the target showing antagonistic effects. In addition, cefixime and amoxicillin antibacterial spectrum is also repeated, if taken at the same time may lead to accelerate the production of bacterial resistance; and the two in the process of static drip will occur in the decomposition, will be combined with the human body protein formation of penicillin thiazole proteins, which can make the patient appear allergic reactions. Patients may experience adverse reactions such as nausea, vomiting, and diarrhea after taking cefixime and amoxicillin. Cefixime and Amoxicillin is contraindicated in people who are allergic to Cefixime and Amoxicillin. If you need to use the above drugs, it is recommended to use them under the guidance of a doctor, and in case of discomfort, it is recommended to go to the hospital for treatment.