Both Marburg and Ebola viruses are filoviruses, which are the more lethal agents of human infection, with rapid onset and easy progression to infectious shock. There is evidence that both may be incubated in small animals and then spread to humans. Although the clinical manifestations are similar and there is no specific treatment, there are some differences in the pathogen, discovery time, incubation period, immune antigenicity, vaccine, etc.: 1, pathogen: although Marburg virus and Ebola virus are filoviruses, they are two completely different viruses; 2, discovery time: Marburg virus is 1967, while Ebola virus is 2014 The incubation period of Marburg virus is usually 3-9 days after infection, while the incubation period of Ebola virus is usually 2-21 days; 4. The body’s response to Ebola virus is stronger, while the response to Marburg virus is relatively weak; 5, vaccine: Marburg virus does not have a vaccine, Ebola virus has been developed, in the further validation. It should be noted that the Marburg virus and Ebola virus in the clinical manifestations, treatment and transmission methods are relatively similar. The initial symptoms are only fever, muscle pain, joint pain, and general malaise, and are not specific. They are usually similar to malaria, SARS, influenza or yellow fever. Late symptoms can include internal bleeding, such as vomiting blood, runny nose, etc. They can also affect the lungs, gastrointestinal tract and central nervous system, involving multiple organs, and in severe cases, shock.