Survival period of stage III kidney cancer varies from person to person, generally the five-year survival rate is about 20%-60% after active treatment. Stage III kidney cancer is staged in middle or late stage. In intermediate stage kidney cancer, cancer cells can invade neighboring organs and symptoms are obvious. The disease is more serious than early stage kidney cancer, which can be treated by surgery and the survival rate is 60% in five years. Advanced kidney cancer, with distant metastasis, has the lowest survival rate. It mainly adopts comprehensive treatment program mainly based on anticancer drugs, with 20% survival rate in 5 years and extremely high mortality rate. Early stage kidney cancer can be cured for most of the patients if it is detected, diagnosed and treated early. For patients with advanced kidney cancer, active treatment is also important. Active treatment of stage III kidney cancer according to doctor’s instruction is the key to prolong survival. If it can be combined with chemotherapy, radiotherapy, immunotherapy, targeted drug therapy, biological therapy and other comprehensive treatments, it can coexist with the tumor for a long time, but the exact time varies from person to person.