Lymph node enlargement as big as a peanut, there are many causes, the severity of the disease and the cause of the disease has a direct relationship. 1. Connective tissue diseases: such as systemic lupus erythematosus, tuberculosis, etc., can lead to part of the lymph nodes are invaded and enlarged, to be glucocorticoid (such as prednisone, etc.), immunomodulators (such as cyclophosphamide, etc.), the treatment can be gradually recovered, the general condition is not serious. 2. Lymphadenitis: mostly caused by bacterial, viral, fungal or tuberculosis infection. After diagnosis, antibiotics, antiviral, antifungal and anti-tuberculosis drugs can be used. Some infections such as chronic lymphadenitis and tuberculous lymphadenitis require prolonged treatment, but are generally not serious. 3. Malignant diseases: such as lymphoma, lymphoblastic leukemia, lymphatic metastasis of malignant tumors, can lead to enlargement of some lymph nodes. Although the lymph nodes are only as big as peanuts, the condition is often very serious and requires active anti-tumor and other treatments. It is recommended that patients seek medical treatment in a timely manner, complete all auxiliary examinations, clarify the cause of the disease, and give appropriate treatment by professional physicians for the condition.