Felodipine extended-release tablets and Irbesartan can be used in combination when the condition requires. Clinical treatment of hypertension can be carried out by using antihypertensive drugs alone or in combination. Treatment should start with a small dose, often after taking a single drug treatment, can not achieve the desired effect of lowering blood pressure, then need to use a combination of drugs for antihypertensive treatment. Common combination therapy programs include ACEI/ARB combined with dihydropyridine CCB, ACEI/ARB combined with thiazide diuretics, and dihydropyridine CCB combined with thiazide diuretics. Felodipine extended-release tablets belong to dihydropyridine CCB, Irbesartan belongs to ARB, so these two drugs can be combined to lower blood pressure treatment. After taking felodipine extended-release tablets, it can reduce the extracellular calcium ions into the vascular smooth muscle cells, thus reducing the contraction response of the resistance vessels, and play a role in lowering the blood pressure, but for the drug component allergy is prohibited, and in the process of taking need to detect the blood pressure, and pregnant women and breastfeeding women need to be under the guidance of a doctor to use the drug. Irbesartan can effectively block the vasoconstriction of angiotensin II receptors, thus exerting the effect of lowering blood pressure. Dizziness, headache, nausea, vomiting and other discomforts may occur after taking the drug. It is contraindicated for those who are allergic to the components of the drug. Liver and kidney function and blood pressure should be tested during the course of the drug. Pregnant and lactating women should use the drug under medical supervision. If you need to use felodipine extended-release tablets in combination with irbesartan for antihypertensive treatment, it is recommended to consult a cardiovascular department in a timely manner, and after a comprehensive assessment of the condition by the doctor, decide on the dosage of the drug and learn the precautions to be taken, and standardize the use of the drug according to the doctor’s instructions.