Sertraline discontinuation is generally seen in two situations, the first is that patients do not tolerate the side effects of sertraline, even in small doses it is difficult to adapt to it can be directly discontinued. The second is that sertraline can be discontinued gradually after the completion of standard treatment and after a full course of treatment, which can be divided into the following categories: 1. some patients can reduce half of the original dose within 3 days, and then reduce the other half of the dose after 3 days if there is no discomfort, and then discontinue the drug. 2. some patients may need to reduce 1/3 of the original dose first, and then reduce 1/3 of the original dose after 1-2 weeks. 3, some patients are more troublesome to stop the drug, after the above two kinds of discontinuation will be symptomatic rebound or rekindle, you can moderately increase the dose, wait until the withdrawal reaction or symptomatic rebound situation disappeared and then more slowly to reduce the dose, such as reducing the original 1/4 of the dose or 1/5 of the dose, and then observe for a longer period of time, such as 2-3 weeks or even 1 month to adjust the dose. The dose should be adjusted once a week or even once a month. Some patients may find it more difficult to stop taking sertraline and put it into 100ml of water or a drink and drink 1% less every 1 week, then gradually reduce the dose until you stop taking it.