Non-lactating mastitis is not treated with anti-inflammatory medications that don’t work, and can be treated with medications such as glucocorticoids, immunosuppressants, or surgical excision. Non-lactating mastitis is a chronic inflammatory disease that is usually associated with a person’s immune system. The course of the disease is usually characterized by a repetitive nature, and it can present as a localized lump in the breast, or it may develop an abscess, which can be difficult to treat. If anti-inflammatory drugs do not work, glucocorticoids such as methylprednisolone can be used to suppress the inflammatory and autoimmune responses in the breast. In case of refractory chronic mastitis, immune preparations such as methotrexate can be used for treatment. If the condition is recurring and difficult to be cured completely, surgical excision can be chosen. It is recommended that patients consult a doctor in time, choose the medication under the guidance of a professional doctor, and take the medication according to the doctor’s instructions, so as not to affect the recovery of the condition.