Post-dose reactions to pentavalent rotavirus vaccine are minor and usually subside on their own without treatment. Pentavalent rotavirus vaccine can prevent rotavirus enteritis and generally there is no adverse reaction after use. However, everyone’s constitution is different, and some people may have some adverse reactions after use, such as fever, diarrhea, loss of appetite, nausea and acid reflux, etc. However, the symptoms will be mild and usually subside in about 2 to 3 days without special treatment. Before using pentavalent rotavirus vaccine, make sure that no other vaccine has been used within two weeks and do not eat for thirty minutes before or after use. If the adverse reaction persists or worsens, it is important to consider whether there is another cause, and to go to the hospital for further examination and to formulate appropriate treatment for the specific cause.