Urinary tract infections are a common and frequent disease in women. The majority of urinary tract infections are due to the upward movement of bacteria, and women have a shorter urethra, so the chances of upward infection are greater than in men. The bacterial colonization of the urinary tract is determined by the number of bacteria, their virulence and the resistance of the patient. Urinary tract infections in postmenopausal women are due to decreased estrogen levels, which have the ability to maintain proper glycosuric stores in the vaginal epithelium and supply the growth of lactobacilli, which can maintain normal vaginal pH at 4.5 or lower, thus reducing or inhibiting pathogenic bacteria around the urethra and reducing the frequency of urinary tract infections in women, and decreased estrogen levels make these protective effects less frequent. Menopausal women with recurrent urinary tract infections should first consult a gynecologist to check the thickness of the endometrium and the presence of mammary gland hyperplasia. If there are no contraindications, local or systemic estrogen supplementation can be used to significantly reduce the incidence of urinary tract infections and improve the quality of life in some patients.