Early diagnosis and early treatment of acute appendicitis is the key to avoid many complications, generally speaking, the shorter the time from the onset of abdominal pain to the diagnosis of acute appendicitis, the better. However, once the appendix exceeds this time, it will adhere to the surrounding intestinal canal, the wall peritoneum and the greater omentum to form an inflammatory mass that is difficult to remove surgically, and if the appendix has suppurated or even perforated, it is more likely to form an appendiceal abscess and acute diffuse peritonitis, leading to more serious consequences and dangers such as toxic shock. For patients with the onset of infection for more than 72 hours, anti-infection treatment is recommended to control the inflammation and gradually release the adhesions formed between the appendix and the surrounding intestinal tissues, and then perform appendectomy after three months. However, if the patient’s abdominal pain and fever do not improve after anti-infection treatment, and the blood picture even gets higher, emergency surgery is necessary. The real appendectomy can only be performed three months later. Therefore, if the appendix can be surgically removed in one stage, more troubles and complications can be avoided. Of course, many patients with appendicitis may not have been sick for more than 72 hours for their own reasons, but what I am emphasizing is that the doctor has diagnosed (or mainly considered) acute appendicitis and the patient does not want to operate for their own reasons (e.g., fear of surgery, lack of care for the elderly or children at home, too busy at work or school, insufficient knowledge of the dangers of appendicitis, etc.). Many of them think they are lucky. Many people take a chance and think that it’s okay to have a drip and that it’s not a big deal if their stomach doesn’t hurt anymore, but the majority of patients have a high probability of having another recurrence of appendicitis or even another acute perforation of the appendix with abdominal pain later. I have seen many such patients in the clinic who regretted after the complication. But it is better not to take regret pills. There are too many painful lessons! Just like the rear end of a moving train, the cost is too great! So I emphasize again: if you are diagnosed with acute appendicitis and the duration of the disease does not exceed 72 hours, please follow the doctor’s advice and get emergency surgery right away! I hope we can all respect science, and I hope all patients can recover and have good health as soon as possible!