There is no authoritative clinical evaluation of the consequences of long-term use of Methylphenidate Extended-Release Tablets for the time being, and if long-term use requires strict compliance with medical advice, some patients may experience adverse reactions such as infections, insomnia, skin rashes, abdominal pain, and so on. Prolonged abuse can lead to significant tolerance and psychiatric dependence. Methylphenidate Extended-Release Tablets are psychostimulants and can be used for short-term or long-term use in the treatment of attention deficit hyperactivity disorder. Patients on long-term medication need to be evaluated according to their condition, age, weight, and functioning in the absence of medication, and the dose of medication should be strictly controlled and reviewed on a regular basis. In general, long-term use of Methylphenidate Extended-Release Tablets in strict compliance with medical advice does not have serious consequences. Some patients may experience adverse reactions, such as infections, insomnia, skin rashes, abdominal pain. Prolonged abuse of the drug can lead to significant tolerance and psychiatric dependence, accompanied by varying degrees of behavioral disorders. Especially when the drug is abused by the non-intestinal route, it can cause significant psychotic episodes. Because discontinuation of the drug of abuse may cause severe depression, the process of its discontinuation should be monitored. If long-term use of Methylphenidate Extended-Release Tablets is required, the medication should be used in strict compliance with the doctor’s instructions and should be actively reviewed.