The removal of three-quarters of the stomach is more serious and can result in partial impairment of the patient’s digestive system, but the patient should be treated aggressively. Three-quarters of the stomach removed, in the short term may occur gastric cavity bleeding, anastomotic stenosis caused by obstruction, anastomotic fistula and so on. If not properly cared for, it may also cause gastric infection, resulting in localized edema and intestinal obstruction. Removal of three-quarters of the stomach will also reduce the size of the stomach lumen, leading to a decrease in the amount of food intake, which will cause malnutrition. After most of the stomach is removed, the patient may experience weight loss, yellowish color (yellow and lusterless), anemia, etc., but these symptoms are acceptable relative to the treatment of the disease. In daily life, patients should eat small, frequent meals, avoid starvation, and avoid overexertion. Patients who have had a major portion of their stomach removed should be in a proper frame of mind and actively treat their disease, and should seek medical attention if they feel unwell to avoid delaying their condition.