If we look at the face, the nasolabial base and the nasolabial folds are both in one location, but if we look at the anatomy, they are not the same location, they are two levels. From the frontal viewpoint, the nasolabial fold is a depression in the soft tissue, which is superficial, between the skin and the muscle, and the nasolabial fold is a depression on the facial bone, which are two completely different levels. Therefore, when doing nasal base filler, the material often used is tumescent, and a small opening is made through the vestibular groove of the mouth, and then it is put in to fill up the depression, which is one way. There is also a more advanced way, through 3D printing technology, the design is done according to the CT data before the surgery, and then the right size prosthesis is placed and fixed in the surgery, which is another way. The most used prosthesis is PEEK, which is a polyether ether ketone material. Its similarity to bone in terms of modulus of elasticity and hardness makes it a more popular application. For silicone, which is often asked, I personally do not recommend it much. Because silicone has the problem of displacement, it is possible to poke the nasal mucosa through the nasal cavity and fall out of the nasal cavity after moving slowly. It is difficult to grow together with the surrounding tissues, so if you have to use silicone, you need to consider using screws to fix it, otherwise, it is not recommended. If you have to use silicone, you need to consider using screws to fix it. For the filling of nasolabial folds, the easiest way is to use hyaluronic acid. Of course, I would like to urge you to use large molecule hyaluronic acid as much as possible, because its displacement is relatively small. Small molecule hyaluronic acid is not recommended, although the position is correct at that time, but with the movement of the face, the extension of time, etc., it may run to the position of the apple muscle and make the nasolabial folds deeper instead. The choice of material for nasolabial folds is collagen, ADM particles, and autologous fat, which I recommend. Autologous fat is relatively the most cost-effective. However, it is more troublesome to do it two to three times, and each time it needs liposuction. But once the fat is alive, it is permanent and you don’t have to worry about it later.