The most common adverse reaction to penicillin is allergic reaction to the drug, and in severe cases, anaphylactic shock may occur, manifested by respiratory distress or even hypotension and shock. In addition, prolonged use of the drug is also prone to secondary liver or renal function damage, manifested as yellow staining of the skin and mucous membranes, serious transaminases and bilirubin increase, induced liver failure. Patients with renal insufficiency will have decreased urine output, and laboratory tests will also indicate that there is an increase in blood creatinine and urea nitrogen, and the patient will also show peripheral swelling, secondary increase in blood pressure, and proteinuria. In addition, prolonged use of medication is also prone to phlebitis, especially when the infusion rate is relatively fast or the drug concentration is relatively high, it is easy to develop this common vascular complication. Therefore, attention should also be paid to the protection of blood vessels during treatment, and if necessary, it can also be combined with local hot compresses.