High fever can have some effects on kidney function. High fever is due to the fact that after the body is attacked by bacteria, viruses and pathogenic microorganisms, such as mycoplasma and chlamydia, or fungi and other substances, the body produces some endogenous pyrogen, such as interleukin, tumor necrosis factor, bradykinin, leukotriene, prostacyclin and so on. The accumulation of these substances in the body will cause high fever at the same time, it will also cause different degrees of stimulation and load on the kidneys and liver, so high fever will appear to have an impact on the function of the kidneys. In addition, patients with high fever for a long time will also have a certain degree of dehydration, dehydration patients will have obvious ionic disorders, which will also cause different degrees of burden and load on the kidney function, so there will be an impact on kidney function. Therefore, when choosing antimicrobials, anti-inflammatory drugs and antipyretic drugs for high fever, try to choose the drugs that minimize the impact and damage to kidney function.