Acute infarction of the pontine brain, with complex symptoms and diverse signs, is a more serious form of ischemic stroke. Pontocerebral infarction is caused by occlusion of the main trunk of the basilar artery and its branches. Occlusion of one side of the artery can lead to oculomotor disorders, peripheral facial paresis, contralateral hemiparesis, contralateral hemianesthesia, affected hemianesthetic ataxia, and symptoms such as vertigo, nausea, and vomiting. In contrast, with bilateral basilar artery occlusion, patients may develop an atresia syndrome, which may manifest as consciousness, preserved language comprehension, but inability to speak, accompanied by restricted horizontal eye movements, and symptoms such as bilateral facial paresis, bilateral central paresis, dysphagia, and dysarthria, which are often mistaken for a comatose state. Intravenous thrombolysis and endovascular therapy are preferred for treatment. Thrombolysis and endovascular therapy can recanalize the occluded arterial vessels, restore effective blood perfusion, and improve symptoms. Infarction of the cerebral bridge has a poor prognosis and a high mortality rate.