Doose syndrome, also known as epilepsy with myoclonic-astatic seizures EMAS, was first reported by Doose et al. in 1970, when it was called myoclonic-astatic petit mal It is a rare epilepsy syndrome, accounting for about 1% to 2% of epilepsy in children under 9 years of age. Myoclonic-asthenic epilepsy is classified as symptomatic or cryptogenic epilepsy. few of the cases reported to date have an acquired etiology, and only 16% of patients have abnormal intellectual development prior to the onset of epilepsy. 32% of children have a family history of febrile convulsions or epilepsy, and family members often have EEG abnormalities such as photosensitivity reactions and spikes and slow waves. These phenomena suggest that genetic susceptibility plays an important role in the development of the disease. The new classification lists it among the idiopathic generalized epilepsies. The growth and neurological examination is normal before the onset of the disease. The age of onset is mostly within 6 years, with a peak of 2-5 years. 24% of children have febrile convulsions or no febrile convulsive seizures within 1 year of age. They are more common in boys (73.5%). The main seizure manifestations are myoclonic, atonic or myoclonic standing inability seizures. Myoclonic seizures mainly involve the upper extremities and shoulders bilaterally, with varying degrees of nodding or falling episodes. The inability to stand is caused by an atonic seizure. The two forms of seizures appear together as a myoclonic inability to stand seizure, in which the child is unable to maintain muscle tone after a single or several consecutive myoclonic jerks, resulting in a fall. Myoclonus of the face and local or generalized loss of muscle tone may also be present. There may be atypical disorientation and generalized tonic-clonic seizures, but rarely partial or tonic seizures. When there is a persistent state, the child shows hazy sluggishness, irregular muscle twitching of the face and limbs, salivation, and frequent head nodding, which can last for several hours to several days. EEG features] Theta rhythms of 4-7 Hz predominantly in the parietal region can be seen during the interictal period, and 4 Hz rhythms can be seen in the occipital region with persistent emission and suppression when the eyes are open. Spike-and-slow wave activity is often accompanied by mild seizures, and sleep can activate spike-and-slow wave emission. The EEG during myoclonic seizures shows irregular spike-and-slow-wave, multiple spike-and-slow-wave transient bursts in full conduction, and irregular, rhythmless spike-and-slow-wave activity (myoclonus) suddenly turning into high-amplitude slow-wave activity (atonia) during myoclonic a standing inability to seize. There may be alternating left- and right-side spikes and slow waves, but there is rarely a constant limiting discharge. In the sustained state, the EEG shows irregular polymorphic hypersynchronized activity, sometimes resembling peak rhythm disturbance. Diagnosis and differential diagnosis】 Diagnosis is made mainly based on clinical manifestations and EEG features. The child is otherwise normal except for seizures, has recurrent drop seizures or a prolonged hazy state, and the EEG shows rhythmic theta activity or irregular spike-slow waves or multiple spike-slow waves. Neuroimaging and other laboratory tests were normal. To differentiate from Lennox-Gastaut syndrome, long-range video EEG and multiconductor physiologic recording EEG monitoring is required to observe the seizures. The syndrome needs to be differentiated from benign myoclonic epilepsy of infancy (BME), Dmvet syndrome, Lennox-Gastaut syndrome (LGE), and atypical benign partial epilepsy of children. These childhood epilepsy syndromes all have myoclonic or multiple forms of seizures and are identified mainly based on age of onset, type of first episode, EEG features and prognosis. Treatment and prognosis] Treatment depends mainly on the type of seizure. Valproic acid is effective for all seizure types. Other antiepileptic drugs such as ethosuximide, benzodiazepines, phenobarbital, and lamotrigine may also be effective. However, phenytoin sodium, carbamazepine, and aminoglutethimide should be avoided. Clonidine or ACTH may be used in cases of persistent epilepsy. The prognosis of this disorder is uncertain. Some children start with multiple forms of seizures that are not controlled by various antiepileptic drugs, but later improve progressively and the drugs can be gradually withdrawn after about 3 years. Half of the patients eventually remit and have a good prognosis. Most patients have normal or near normal intelligence. In some patients, seizures remain uncontrolled and cognitive-behavioral impairment occurs. Recurrent early onset of persistent status epilepticus is an important factor contributing to poor prognosis.