Atrophic gastritis pain in the middle of the night is usually treated with medication, and surgery should be considered for severe cases. 1. Pharmacological treatment: atrophic gastritis pain in the middle of the night is recommended to give the eradication of Helicobacter pylori treatment, that is, 1 kind of proton pump inhibitor + 2 kinds of antibiotics and 1 kind of bismuth, such as Omeprazole, Clarithromycin, Metronidazole, Bismuth Potassium Citrate and so on. Acid-suppressing or antacid treatment such as ranitidine, aluminum thioglycollate, etc., gastric mucous membrane protectant such as bismuth potassium citrate, ekabete, etc., and power promoter such as domperidone. 2. Surgical treatment: for atrophic gastritis pain in the middle of the night drug effect is not good, the symptoms are serious, it is recommended to choose timely medical treatment, combined with the condition of the consideration of endoscopic surgery or surgical treatment. In addition, atrophic gastritis pain in the middle of the night may also be related to other diseases, if the symptoms have not improved or aggravated and accompanied by other symptoms, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor to clarify the cause and targeted treatment, do not take medication, so as not to delay the condition.