Parkinson’s syndrome refers to a group of clinical syndromes caused by a variety of reasons, mainly motor retardation, which is characterized by tremor, muscle stiffness, slow movement or postural instability. Therefore, a clinical diagnosis of Parkinson’s syndrome requires the presence of bradykinesia and at least one of the two symptoms of tremor or muscle rigidity. The causes of Parkinson’s syndrome are diverse and include primary Parkinson’s disease, Parkinson’s superimposed syndrome, secondary Parkinson’s syndrome, and hereditary degenerative Parkinson’s syndrome. Common causes of secondary Parkinson’s syndrome are pharmacological, toxic (MPTP, manganese, CO, methane), metabolic disorders (parathyroidism, hypothyroidism, acquired hepatic encephalopathy), vascular, encephalitis or post-infectious, normal-intracranial-pressure hydrocephalus (NPH), age-related gait disorders, post-traumatic, space-occupying lesions (subdural hematomas, neoplasms), and paraneoplastic tumors. Today we mainly talk about drug-induced Parkinson’s syndrome (DIP). 1, the definition of DIP Drug-induced Parkinson’s syndrome (DIP) refers to the use of drugs that may lead to a reduction in the dopamine transmitter content in the striatum or blockade of dopamine receptors, which appear as a series of Parkinson’s clinical manifestations such as dyskinesia, tremor, autonomic dysfunction, etc. [1-3], and it is a common cause of secondary Parkinson’s syndrome. Clinical signs and symptoms of DIP are similar to those of PD, and some DIP patients may combine with non-motor symptoms such as constipation and mood disorders, which makes clinical differential diagnosis more difficult, and can easily lead to omission or misdiagnosis, so it is especially important to recognize DIP at an early stage and intervene as soon as possible. 2.Clinical manifestations and characteristics of DIP DIP usually manifests as hypokinesia/retardation and rigidity, which progresses rapidly. Clinical tremor is rare and usually presents as postural/motor tremor of the upper extremities bilaterally. Patients with DIP due to antidepressants, peripheral and central dopamine receptor antagonists, and first-generation antihistamines most often develop rigidity, whereas DIP due to calcium channel blockers is more commonly characterized by tremor. Compared with PD, DIP often has the following clinical features [4]: ① elderly people are more common, more women; ② the average time from the drug to the onset of the disease is 3 to 4 months, the shorter a few days, a few weeks, the longer up to 1 to 2 years; ③ the disease progression after the onset of the disease is more rapid, the symptoms are often symmetrical; ④ to the movement of reduced and increased dystonia as the main manifestations of the tremor is more to the movement and postural tremor, the dystonia is more often to The main manifestations of DIP are decreased movement and increased muscle tone, tremor is mainly motor and postural tremor, and increased muscle tone is mostly lead pipe-like; ⑤ often accompanied by mental symptoms such as sluggishness, depression, agitation and the inability to sit still; ⑥ the symptoms are often reversible, and most of the symptoms can be alleviated within a few weeks and disappear within 1 to 3 months once the medication is terminated, and there are some cases that lasted for one year; ⑦ it is difficult to take the anti-Parkinsonian medication, such as levodopa, and the anti-cholinergic medication is effective. 3.Common drugs causing DIP The classification of common drugs causing DIP and the possible mechanism of action are listed in the following table: 4.Treatment and prevention of DIP Drug-induced Parkinson’s syndrome is related to the dose size. If it is simple DIP, anti-PD drugs can be used without, most DIP is reversible, the vast majority of patients can significantly reduce or disappear the symptoms of Parkinson’s syndrome after stopping the drug for a few weeks to 6 months, without the need for drug treatment. If DIP is initially considered and the clinical symptoms are not reversible after discontinuing the responsible drug, it may be a drug-induced early onset of PD, and if the diagnosis can be clarified, anti-PD therapy can be given. Because DIP is more common in clinical practice and more difficult to treat, prevention is extremely important, and clinical drug use should pay attention to the following points: 1) the history of adverse drug reactions should be clarified before use of the drug; 2) strictly grasp the indications, avoid the use of drugs that are known to cause DIP, and if clinically necessary to use, a safer alternative should be chosen as far as possible, and the drug should be used with a small dose to begin with, and the course of treatment should not be too long, and the process of use should be followed up closely to follow up the drug. The medication should be started in small doses, the course of treatment should not be long, and the process of medication should be followed up closely to pay attention to the occurrence of DIP, and once it occurs, it should be given timely treatment.