Why do tumors that have been removed recur?

The fact that resected tumors will recur is mainly determined by the biological characteristics of tumor cells. Tumor cells have basic biological characteristics such as malignant proliferation, poor differentiation, infiltration and metastasis. Tumor cells require significantly less growth factors because of the activation of autocrine or other cell proliferation signaling pathways, and certain solid tumor cells are also able to release angiogenic factors that promote vascular growth toward the tumor and obtain nutrients needed for massive multiplication. While most normal eukaryotic cells must adhere to a specific extracellular matrix to survive, tumor cells lose their anchorage dependence and can continue to grow on supports such as aglycones and methylcellulose. In addition, malignant tumors are also infiltrative and metastatic in nature. Normal cells are restricted from spreading to nearby and distant sites because of certain adhesion between each other, while tumor cells have mutations or absence of surface cell adhesion, and connection-related components, and relevant signaling pathways are blocked, and the cells lose intercellular and extracellular matrix interconnections, which can easily detach from the primary site and invade into surrounding tissues, or invade into blood, lymphatic tissue and spread to other parts of the body through blood and lymphatic fluid circulation, causing tumor cells to spread and metastasize. Therefore. The excised tumor will also have the possibility of recurrence.