Closed-cell acne medically refers to acne, a chronic inflammatory skin disease of the sebaceous gland units of hair follicles. It is a chronic inflammatory skin disease of the sebaceous gland units of the hair follicles. Repeatedly growing closed mouth on both sides of the cheeks is mainly related to factors such as heredity, diet, environment and hygiene habits. 1. Genetic factors: acne is also known as acne vulgaris, acne vulgaris belongs to a special type of acne, the development of its existence has a certain genetic predisposition, for people with a similar family history, the chances of disease will increase significantly. 2. Dietary factors: Poor dietary habits can aggravate the secretion of sebaceous glands, and excessive sebum secretion accumulates on the skin surface, which can easily lead to Propionibacterium acnes infections, which is also the cause of recurrent closed-cell pimples on both sides of the cheeks. 3. Environmental factors: due to the harsh environmental conditions, the skin is easily affected by some dust or dirt and induced infection, which is also the main cause of acne on the face and other exposed parts of the skin. 4. Hygiene habits: Irregular work and rest as well as bad habits such as not paying attention to hygiene will aggravate the chances of skin infection. There are many reasons why acne can affect the face, and it is recommended that patients go to the hospital in time for standardized treatment under the guidance of the doctor.