Diabetic foot lesions are changes in the feet of diabetic patients that are caused by insufficient blood supply due to vascular lesions, sensory loss due to neuropathy and associated with infection. The number of amputations due to diabetic foot lesions is 5 to 10 times higher than in non-diabetic patients. In fact, similar pathological changes can occur in other parts of the body, but the incidence of foot lesions is significantly higher in patients than in other parts of the body. The main manifestations of the diabetic foot include lower extremity pain, skin ulcers, and from mild to severe can manifest as intermittent claudication, lower extremity rest pain, and foot gangrene. In the early stage of the disease, physical examination can reveal the manifestation of insufficient blood supply to the lower extremities, such as pale skin of the foot when the lower extremity is elevated, and then purplish when the lower extremity is lowered. The foot is cold and the dorsalis pedis artery pulsation is weakened to absent. Intermittent claudication is when the patient sometimes walks and suddenly feels pain in the lower limbs to the point of having to walk with a limp. Rest pain is the result of further development of vascular lesions in the lower extremities, not only is the blood supply to the lower extremities insufficient when walking, but the lower extremities are also painful at rest due to blood loss. In severe cases, patients may have trouble sleeping at night. Further development of the disease, the lower extremities, especially the feet can appear necrosis, wounds do not heal for a long time, serious cases have to be amputated to disability. The etiology of diabetic foot is multifactorial. Diabetic neuropathy, peripheral vascular disease and microcirculatory disorders are the main causes, which can exist alone or in combination with other factors, and other factors such as structural deformities of the foot, abnormal gait, skin or toenail deformities, trauma and infection are also important triggers for the development of diabetic foot. Diabetic feet are particularly susceptible to vascular and neurological lesions, which interact with each other to cause a range of clinical foot conditions, including toe disease, callus formation, skin damage and foot ulcers, and musculoskeletal lesions leading to foot deformities. Diabetics are often susceptible to trauma due to neuropathy leading to foot dissipation or decompensation, and minor trauma can quickly lead to ulceration, infection and gangrene, resulting in the eventual necessity of amputation. The prevalence of diabetic foot has increased significantly, which is related to the following factors: 1, the global increase in the number of people with diabetes; 2, the increase in the life expectancy of diabetes and therefore the duration of diabetes; 3, the increase in the aging population. The prevalence of diabetic foot is reported differently from country to country, accounting for about 6-12% of hospitalized diabetic patients, more than 40,000 diabetic amputees each year in the United States, in fact, 50% of non-traumatic amputees are diabetic patients, the risk of lower limb amputation in diabetic patients is 15 times that of non-diabetic patients.