According to the patient’s neurological symptoms, neuroimaging findings, neuropsychological evaluation combined with the ignition and conduction characteristics of epileptic discharges, the epilepsy distinction is determined as five levels from mild to severe; according to the pathological characteristics of these five levels of epilepsy hierarchy to give the corresponding standardized scientific, from simple to complex step-up treatment plan. Grade I epilepsy is characterized by a single seizure type, short duration of illness, low seizure frequency, and non-persistent epileptic discharges. It can be cured or well controlled through a period of systematic and scientific use of Chinese and Western medicines and some other methods. Grade II epilepsy is a relatively fixed and limited epileptic focus, and there are about 2~3 million patients in this grade. The epileptic foci can be completely removed by means of craniotomy to achieve a cure. Grade III epilepsy has abnormal discharges distributed in multiple brain regions. Patients in this grade have about 1~2 million, and complete removal treatment by craniotomy is impossible to complete. Patients in this grade can be treated with neuromodulation procedures such as vagus nerve stimulation and brain pacemakers, and satisfactory results can be obtained. Grade IV epilepsy with widespread diffuse epileptic discharges in all brain regions bilaterally is present in about 1 million patients. Patients in this grade can be treated with neural stem cell transplantation to obtain a good prognosis. Epilepsy grade V is a mixed grade of grade 2 to 4 conditions, with more intractable epilepsies falling into this grade. It requires a combination of craniotomy, neuromodulation surgery and cell transplantation, and is a systematic and comprehensive treatment project. It is easy to see that accurate grading is the most important basis for the correct choice of treatment and is the fundamental prerequisite for good or bad treatment results. For epilepsy, which is one of the five major neurological problems in the world, only such a hierarchical, systematic and integrated treatment process can achieve the best treatment results.