Tingling and coldness of the toes is considered to be peripheral neuritis, which is manifested as tingling and coldness of the toes, or tingling and coldness of the endings of the limbs in severe cases, which can be investigated by electromyography. For treatment, patients can be given oral nerve-nourishing drugs, such as vitamin B12 and methylcobalamin. Numbness and coldness of the toes can also be seen in some patients with Raynaud’s disease. Due to autonomic dysfunction and vasodilatation abnormality, manifested as tingling and coldness of the toes, and may be accompanied by changes in the color of the toes, if necessary, acupuncture or oral relief of vasodilatation dysfunction of the drug.