Waking up with spinal pain in the morning: 1, the most serious should be ankylosing spondylitis, which can lead to symptoms of spinal pain when waking up in the morning, which is an immune system disorder that often leads to pain in the back when waking up in the morning, accompanied by symptoms of morning stiffness, which can be slightly improved by activity. If you have such obvious symptoms, you must go to the hospital in time to improve the B27 examination, as well as the x-ray of the sacroiliac joint to confirm the diagnosis and choose a reasonable treatment. 2, due to the cold at night, it can also lead to muscle spasms in the morning and the symptoms of localized pain in the back. In fact, the most common reason for waking up with pain in the spine in the morning is due to sleeping in a more inappropriate bed at night, overstretching the muscles of the back during sleep, resulting in muscle strain, leading to the symptoms of pain in the back of the spine when waking up. If there is no relief within a short period of time, you must go to a regular hospital promptly.