There is no change after two courses of chemotherapy, indicating that the patient is currently stable and the treatment is still effective. The patient’s lesions did not shrink after two courses of chemotherapy, indicating that the patient’s condition is stable and the treatment is judged to be effective, which is good news for the patient. You can continue chemotherapy, observe 1~2 courses, further evaluate the efficacy according to the examination results, adjust the treatment program, more objective and accurate. Chemotherapy is an important means of treating malignant tumors. For patients who are unable to undergo surgical resection, chemotherapy can be considered as a first step to shrink the lesion and then decide whether to operate or not according to the treatment. If the lesion persistently fails to shrink or keeps increasing in size, the chemotherapy drug should be changed or combined with other treatment modalities such as radiotherapy and targeted therapy. Therefore, evaluation should be conducted after 2 to 4 cycles of chemotherapy to assess the efficacy and whether the next treatment plan should be adjusted.