Colorectal cancer is a common malignant tumor of the gastrointestinal tract. Since the creation of the Miles procedure in 1908, the 5-year survival rate after radical surgery for colorectal cancer is still about 50%, despite improvements in surgical techniques and comprehensive treatment. Since April 2000, we have used interventional catheterized arterial chemotherapy as an alternative to oral and intravenous chemotherapy after radical colorectal cancer surgery, and the results are satisfactory and reported as follows. From April 2000 to November 2009, we performed arteriography and regional chemotherapy for 49 patients with colorectal cancer, including 23 men and 26 women, male:female = 0q96:1, age range 27-85 years, average 58q2 years, 25 cases of rectal cancer, 8 cases of ascending colon cancer, 3 cases of transverse colon cancer, 3 cases of descending colon cancer, 8 cases of sigmoid colon cancer, 1 case of cecum-rectum cancer, and 1 case of rectum descending colon cancer. Forty-one cases underwent surgery, two cases of liver metastasis were found before surgery, eight cases of liver metastasis after surgery, three cases of pelvic metastasis, and four cases of recurrence after surgery. Pathology: 29 cases of moderately differentiated adenocarcinoma, 8 cases of highly differentiated adenocarcinoma, 2 cases of poorly differentiated adenocarcinoma, 8 cases of mucinous adenocarcinoma, and 2 cases of papillary adenocarcinoma; Dukes stage: A: 0 cases, B: 35 cases, C: 10 cases, D: 4 cases. The femoral artery was punctured by the modified Seldinger method, and the superior and inferior mesenteric arteries were imaged with a 5F Cobra catheter to clarify the location of the lesion. Regional chemotherapy is performed, and for some rectal cancers, internal iliac artery angiography and chemotherapy are also performed. If there is difficulty in superselection, the superior mesenteric artery or inferior mesenteric artery will be used for chemotherapy. For patients with liver metastases or pelvic metastases, chemotherapy with hepatic artery and internal iliac artery angiography will be administered simultaneously. One patient with advanced rectal cancer had a chemotherapy pump placed in the inferior mesenteric artery, and one patient with postoperative liver metastasis from rectal cancer had a chemotherapy pump placed in the intrinsic hepatic artery. In all colorectal cancers, the arteriograms showed thickening of the blood supply arteries, increase in the number of terminal branches and disorder, obvious tumor staining in the parenchymal stage, and arteriovenous fistula in some cases. In one patient with postoperative recurrence, sigmoidoscopy only found lesions close to the anus, but missed smaller descending colon lesions, but these lesions were clearly shown on angiography. 22 patients with rectal cancer with different degrees of intestinal obstruction, 20 patients (86%) had improvement of symptoms after arterial regional chemotherapy. The symptoms improved in 20 patients (86%) after arterial regional chemotherapy. In patients with liver metastases from colon cancer, the hepatic arteriogram showed multiple, circumferential tumor staining. For pelvic metastases, internal iliac artery angiography showed patchy irregular tumor staining foci. No intubation-related complications occurred in all cases, and the patients had no significant intraoperative discomfort and were not given sedation or analgesic treatment. All 49 patients survived for more than 15 months, except one case died at 10 months due to coronary heart disease combined with myocardial infarction and two cases died at 13 months due to pulmonary heart disease combined with infection. Among them, 11 cases survived for more than 7 years. The diagnosis of colorectal cancer is usually made by anal finger diagnosis, gas-barium enema and fiberoptic colonoscopy, but due to factors such as poor bowel preparation and long and tortuous colon, the diagnosis is often missed, especially for multiple lesions or small lesions, while DSA can improve the correct diagnosis rate and help the accurate positioning of surgery. In addition, since air-barium enema and fiberoptic colonoscopy are painful, angiography is a less painful and easy-to-accept effective examination method for elderly, frail or other patients who cannot cooperate with the examination. However, the recurrence rate is high due to preoperative and postoperative metastasis, and the 5-year survival rate after surgery is only about 50%. It is reported in the literature that about 10%-25% of colorectal cancer patients have liver metastases at the time of initial surgery, and the recurrence rate after surgery is 12%-50%, and the recurrence rate of rectal cancer with lymph node metastases through the intestinal wall is as high as 40%-65%. In our group, 29% of the patients had metastasis or recurrence. In order to improve the therapeutic effect, a combination of surgical resection and preoperative and postoperative systemic chemotherapy is often used, but the effect is not ideal because of the low local drug concentration and the systemic side effects. Maure et al. showed that the concentration of chemotherapeutic drugs at the tumor margin was 9-68 times higher than that of systemic chemotherapy by regional infusion of arterial chemotherapy for gastrointestinal tumors, and the efficacy of chemotherapeutic drugs, such as oxaliplatin, which are easily bound to plasma proteins, was reduced by arterial infusion. In addition, the efficacy of chemotherapeutic drugs, such as oxaliplatin, which are easily bound to plasma proteins and have reduced efficacy, can be increased by 2 to 22 times and the efficacy can be increased by 4 to 10 times by arterial infusion. Since chemotherapeutic drugs stimulate the tumor blood supply artery, it can cause vasospasm and contraction of the tumor itself, which can reduce intraoperative bleeding after 2 weeks of perfusion. For lesions that cannot be resected at advanced stage, local chemotherapy can be used to improve the symptoms or to obtain the opportunity of surgery. In our group, 22 patients with rectal cancer with various degrees of intestinal obstruction had improvement of symptoms after arterial chemotherapy in 20 cases. 50% of patients with recurrent unresectable rectal cancer had relief of pain by infusion of 5-Fu and MMC into the internal iliac arteries bilaterally. For patients with advanced intestinal obstruction, internal stenting can be used to relieve the symptoms of obstruction and improve the quality of survival. In order to reduce the inconvenience caused by repeated intubation, patients who have lost the chance of surgery, liver metastasis or recurrence can be tried to have a local chemotherapy pump placed through intervention and regular arterial chemotherapy.